Two-stage procedures for selecting the best diagnostic biomarkers
نویسندگان
چکیده
Considered in the paper is the problem of selecting a diagnostic biomarker that has the highest classification rate among several candidate markers with dichotomous outcomes. The probability of correct selection depends on a number of nuisance parameters from the joint distribution of the biomarkers and thus can be substantially affected if these nuisance parameters are misspecified. A two-stage procedure is proposed to compute the needed sample size that achieves the desired level of correct selection, as so confirmed by simulation results.
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عنوان ژورنال:
دوره 366 شماره
صفحات -
تاریخ انتشار 2008